CNOT1

Across TCGA patient cohorts, CNOT1 protein abundance is significantly associated with the protein abundance of many other proteins, with 33,533 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CNOT1-associated proteins across cancer lineages are SF3B1, WDR43, and CNOT11. Each is linked with CNOT1 in more than 9 cancer types. Because this analysis shows association rather than direction, both CNOT1-to-partner and partner-to-CNOT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNOT1 versus SF3B1 in GBM, with a Pearson correlation of 0.76.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT1→partner) and Y-score (partner→CNOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SF3B1 →	+0.256	+0.193	<.001	<.001	3	10
LSCC	WDR43 →	+0.320	+0.139	<.001	<.001	3	10
OV	CNOT11 →	+0.236	+0.132	<.001	<.001	3	10
GBM	CNOT9 →	+0.325	+0.257	<.001	<.001	3	10
GBM	PRPF8 →	+0.254	+0.169	<.001	<.001	3	10
UCEC	CAVIN2_S203 →	-0.784	-0.127	.002	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 33,533 associations by consensus.

CNOT1 vs SF3B1 — GBM

Explore this scatter interactively →