CNOT1

Across TCGA patient cohorts, CNOT1 mutation is significantly associated with the RNA expression of many other genes, with 6,228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT1-associated genes across cancer lineages are PAPLN, ERCC2, and DCPS. Each is linked with CNOT1 in more than 5 cancer types. Because this analysis shows association rather than direction, both CNOT1-to-partner and partner-to-CNOT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAPLN grouped by CNOT1-low versus CNOT1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT1→partner) and Y-score (partner→CNOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PAPLN →	-0.874	-3.689	<.001	.001	3	6
LUSC	ERCC2 →	+0.446	+3.348	.003	.005	3	5
COAD	DCPS →	+0.438	+3.860	<.001	<.001	3	5
COAD	CLUH →	+0.455	+2.097	.001	<.001	3	5
STAD	MTMR4 →	+0.490	+2.338	.003	.003	3	5
STAD	DDX19A →	+0.368	+3.000	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,228 associations by consensus.

PAPLN by CNOT1 expression — BRCA

Explore this box plot interactively →