CNOT1

Across TCGA cell cohorts, CNOT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,846 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNOT1-associated GO terms across cancer lineages are Regulation of centromeric sister chromatid cohesion, mRNA export from nucleus, and mRNA transport. Each is linked with CNOT1 in more than 17 cancer types. Because this analysis shows association rather than direction, both CNOT1-to-partner and partner-to-CNOT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centromeric sister chromatid cohesion grouped by CNOT1-low versus CNOT1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT1→partner) and Y-score (partner→CNOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of centromeric sister chromatid cohesion →	+0.133	+0.776	.002	.004	3	18
BONE	mRNA export from nucleus →	+0.150	+1.087	<.001	<.001	3	16
BONE	mRNA transport →	+0.122	+0.893	<.001	<.001	3	15
BONE	RNA export from nucleus →	+0.142	+0.782	<.001	.001	3	15
BONE	mRNA alternative polyadenylation →	+0.082	+0.858	<.001	<.001	3	15
BLOOD_Myeloma	Positive regulation of mRNA metabolic process →	+0.055	+0.958	.003	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,846 associations by consensus.

Regulation of centromeric sister chromatid cohesion by CNOT1 expression — BREAST

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