CNMD

Across TCGA patient cohorts, CNMD mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNMD-associated genes across cancer lineages are Th2 cells, aDC, and lymphatic Endothelial cells. Each is linked with CNMD in more than 1 cancer types. Because this analysis shows association rather than direction, both CNMD-to-partner and partner-to-CNMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Th2 cells grouped by CNMD-low versus CNMD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNMD→partner) and Y-score (partner→CNMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Th2 cells →	+0.248	+3.177	.003	.010	3	2
UCEC	aDC →	+0.086	+2.177	.012	.035	3	1
UCEC	lymphatic Endothelial cells →	-0.023	-2.531	.040	.012	3	1
UCEC	pDC →	+0.058	+3.202	.011	.009	3	1
UCEC	Eosinophils →	-0.053	-3.121	.037	.019	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Th2 cells by CNMD expression — UCEC

Explore this box plot interactively →