CNIH4

Across TCGA patient cohorts, CNIH4 mutation is significantly associated with the RNA expression of many other genes, with 432 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNIH4-associated genes across cancer lineages are RPS3AP17, OR10A6, and SOCS7. Each is linked with CNIH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNIH4-to-partner and partner-to-CNIH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS3AP17 grouped by CNIH4-low versus CNIH4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNIH4→partner) and Y-score (partner→CNIH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS3AP17 →	+0.090	+2.870	.003	.005	3	2
SCLC	OR10A6 →	+0.079	+5.624	<.001	.003	3	1
UCEC	SOCS7 →	+0.672	+3.329	.008	.005	3	1
UCEC	MIR7976 →	+0.389	+2.646	.005	.009	3	1
UCEC	RPS29P32 →	+0.814	+3.336	<.001	<.001	3	1
UCEC	RN7SL478P →	+0.386	+2.617	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 432 associations by consensus.

RPS3AP17 by CNIH4 expression — UCEC

Explore this box plot interactively →