CNIH3-AS2

Across TCGA pan-cancer cohorts, CNIH3-AS2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CNIH3-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CNIH3-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNIH3-AS2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where CNIH3-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNIH3-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.476	<.001	12	view →
LUAD	Female	II,III,IV	+1.604	<.001	9	view →
COAD	Male	All	+0.636	<.001	9	view →
BLCA	All	III,IV	+0.897	.005	7	view →
BRCA	All	III,IV	+0.585	<.001	6	view →
LUSC	Male	II,III,IV	+1.271	<.001	5	view →
KIRC	Male	All	+0.145	.013	4	view →
THCA	All	All	+0.256	<.001	3	view →
KIRP	All	All	+0.229	.001	3	view →
UCEC	All	All	+0.601	.039	2	view →
KICH	Female	All	−0.138	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CNIH3-AS2–HNSC

Open the HNSC breakdown →