CNGB1

Across TCGA cell cohorts, CNGB1 mutation is significantly associated with the RNA expression of many other genes, with 317 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNGB1-associated genes across cancer lineages are FAM25A, HTR1A, and KRT33B. Each is linked with CNGB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNGB1-to-partner and partner-to-CNGB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM25A grouped by CNGB1-low versus CNGB1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNGB1→partner) and Y-score (partner→CNGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM25A →	+0.112	+4.058	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	HTR1A →	+0.029	+3.510	<.001	.007	3	2
BLOOD_Leukemia	KRT33B →	+0.017	+3.121	<.001	.003	3	2
BLOOD_Leukemia	LBHD2 →	+0.022	+3.984	<.001	.006	3	2
LUNG_SCLC	PSG8 →	+0.109	+3.898	<.001	.005	3	1
LUNG_SCLC	IL36A →	+0.016	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 317 associations by consensus.

FAM25A by CNGB1 expression — LUNG_SCLC

Explore this box plot interactively →