CNGA3

Across TCGA patient cohorts, CNGA3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNGA3-associated genes across cancer lineages are Cyclin-B1, ASNS, and MSH2. Each is linked with CNGA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CNGA3-to-partner and partner-to-CNGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CNGA3-low versus CNGA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNGA3→partner) and Y-score (partner→CNGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.549	+2.000	.005	.003	3	4
UCEC	ASNS →	+0.429	+1.906	<.001	.015	3	4
SKCM	MSH2 →	+0.174	+1.379	.025	.022	3	3
COAD	Cyclin-E2 →	+0.242	+2.178	.026	.035	3	3
UCEC	Rad50 →	-0.252	-3.687	.003	.001	3	3
UCEC	Annexin_VII →	-0.123	-1.362	.012	.037	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Cyclin-B1 by CNGA3 expression — UCEC

Explore this box plot interactively →