CNGA3

Across TCGA pan-cancer cohorts, CNGA3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CNGA3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CNGA3 RNA is repressed in tumor relative to normal tissue. In most cancer types CNGA3 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and BLCA are the cancer types where CNGA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNGA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.169	<.001	11	view →
COAD	All	II,III,IV	−1.003	<.001	9	view →
BLCA	All	All	−0.696	.004	8	view →
UCEC	All	All	−0.498	<.001	8	view →
THCA	All	All	+0.275	<.001	7	view →
BRCA	All	III,IV	+0.355	.002	6	view →
KICH	All	II,III,IV	−0.192	<.001	6	view →
KIRP	Male	All	−0.089	<.001	6	view →
HNSC	All	II,III,IV	−0.077	.018	6	view →
LUAD	Female	All	+0.694	<.001	5	view →
STAD	All	All	−0.556	.002	4	view →
LUSC	All	II,III,IV	−0.155	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CNGA3–KIRC

Open the KIRC breakdown →