CNGA3

Across TCGA cell cohorts, CNGA3 mutation is significantly associated with the RNA expression of many other genes, with 827 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNGA3-associated genes across cancer lineages are GCH1, ALOXE3, and SYCE3. Each is linked with CNGA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNGA3-to-partner and partner-to-CNGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCH1 grouped by CNGA3-low versus CNGA3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNGA3→partner) and Y-score (partner→CNGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GCH1 →	+1.480	+3.199	.002	.007	3	2
BLOOD_Leukemia	ALOXE3 →	+0.211	+3.259	.001	.006	3	2
BLOOD_Leukemia	SYCE3 →	+0.499	+3.259	<.001	.006	3	2
LARGE_INTESTINE	TMEM268 →	+0.682	+3.364	.004	.002	3	2
LARGE_INTESTINE	MOB3A →	+0.785	+3.364	<.001	.002	3	2
SOFT_TISSUE	SMCP →	+0.136	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 827 associations by consensus.

GCH1 by CNGA3 expression — BLOOD_Leukemia

Explore this box plot interactively →