CNGA3

Across TCGA cell cohorts, CNGA3 mutation is significantly associated with the mutation status of many other genes, with 5,858 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNGA3-associated genes across cancer lineages are ACE, JAG2, and PPIP5K2. Each is linked with CNGA3 in more than 5 cancer types. Because this analysis shows association rather than direction, both CNGA3-to-partner and partner-to-CNGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACE grouped by CNGA3-low versus CNGA3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNGA3→partner) and Y-score (partner→CNGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACE →	+4.651	+5.307	<.001	<.001	1	6
LUNG_NSCLC_LUAD	JAG2 →	+3.303	+3.478	.006	.006	1	6
BREAST	PPIP5K2 →	+4.297	+4.857	.009	.009	1	5
SKIN	KCTD8 →	+4.239	+5.053	.007	.007	1	5
LARGE_INTESTINE	TLN2 →	+1.919	+2.921	<.001	<.001	1	5
LARGE_INTESTINE	PDE3A →	+2.696	+3.430	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,858 associations by consensus.

ACE by CNGA3 expression — SOFT_TISSUE

Explore this box plot interactively →