CNBD2

Across TCGA patient cohorts, CNBD2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNBD2-associated genes across cancer lineages are ATM, mTOR, and TSC1. Each is linked with CNBD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNBD2-to-partner and partner-to-CNBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CNBD2-low versus CNBD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNBD2→partner) and Y-score (partner→CNBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.513	-3.156	.007	.018	3	3
UCEC	mTOR →	-0.197	-2.321	.004	.033	3	2
UCEC	TSC1 →	-0.207	-1.700	.004	.044	3	2
UCEC	ERK2 →	+0.206	+3.169	.011	.018	3	1
UCEC	MEK1 →	+0.399	+2.459	.010	.019	3	1
UCEC	MSH2 →	-0.320	-3.433	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by CNBD2 expression — UCEC

Explore this box plot interactively →