CNBD2

Across TCGA pan-cancer cohorts, CNBD2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CNBD2 data layer compared with 8 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CNBD2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CNBD2 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

UVM, UCS, and KIRC are the cancer types where CNBD2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.247	0.681	<.001	114	view →
UCS	DFS	Tertile	II,III,IV	0.639	0.119	<.001	72	view →
KIRC	OS	Tertile	All	0.919	0.844	<.001	56	view →
LIHC	DFS	Median	All	0.455	0.614	<.001	56	view →
CESC	OS	Quartile	IV	0.166	0.695	.001	30	view →
UCEC	DFS	Tertile	All	0.783	0.892	.002	26	view →
PAAD	OS	Tertile	All	0.522	0.280	.002	20	view →
KICH	OS	Median	All	0.864	0.982	.015	17	view →
SCLC	DFS	Median	III,IV	0.557	0.259	.015	17	view →
BRCA	OS	Quartile	III,IV	0.639	0.327	.023	14	view →
GBM	OS	Tertile	All	0.584	0.304	.007	14	view →
OV	DFS	Median	III,IV	0.123	0.185	.029	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CNBD2–UVM (DFS)

Open the UVM breakdown →