CNBD2

Across TCGA cell cohorts, CNBD2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNBD2-associated genes across cancer lineages are FAM25G, GABRG1, and TFDP3. Each is linked with CNBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNBD2-to-partner and partner-to-CNBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM25G grouped by CNBD2-low versus CNBD2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNBD2→partner) and Y-score (partner→CNBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM25G →	+0.554	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	GABRG1 →	+0.012	+4.196	<.001	.002	3	1
LARGE_INTESTINE	TFDP3 →	+0.018	+4.196	.006	.002	3	1
LUNG_NSCLC_LUAD	NXNL1 →	+0.024	+5.228	.004	.005	3	1
LUNG_NSCLC_LUAD	OR5M10 →	+0.019	+5.662	<.001	.002	3	1
BLOOD_Leukemia	C20orf85 →	+0.056	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FAM25G by CNBD2 expression — SKIN

Explore this box plot interactively →