CNBD1

Across TCGA patient cohorts, CNBD1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNBD1-associated genes across cancer lineages are VHL, Notch1, and ASNS. Each is linked with CNBD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNBD1-to-partner and partner-to-CNBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CNBD1-low versus CNBD1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNBD1→partner) and Y-score (partner→CNBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	VHL →	+0.869	+3.169	.025	.019	3	3
UCEC	Notch1 →	+0.183	+2.424	<.001	.001	3	3
UCEC	ASNS →	+0.564	+2.415	<.001	.003	3	3
LUSC	MIG-6 →	+0.182	+2.816	.005	.036	3	2
STAD	eIF4G →	+0.572	+3.000	.026	.034	3	2
STAD	Bap1-c-4 →	+0.452	+3.169	.011	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

VHL by CNBD1 expression — STAD

Explore this box plot interactively →