CMTM8

Across TCGA patient cohorts, CMTM8 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMTM8-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ACC1. Each is linked with CMTM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMTM8-to-partner and partner-to-CMTM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CMTM8-low versus CMTM8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTM8→partner) and Y-score (partner→CMTM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.180	-3.308	<.001	.010	3	1
UCEC	EGFR_pY1068 →	-0.326	-3.321	.013	.010	3	1
UCEC	ACC1 →	+0.538	+2.820	.004	.035	3	1
UCEC	Ku80 →	+0.435	+3.335	<.001	.005	3	1
UCEC	P-Cadherin →	-0.216	-2.990	.004	.036	3	1
UCEC	Shc_pY317 →	-0.213	-3.000	.007	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by CMTM8 expression — UCEC

Explore this box plot interactively →