CMTM8

Across TCGA pan-cancer cohorts, CMTM8 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CMTM8 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CMTM8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CMTM8 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

KIRP, KIRC, and UVM are the cancer types where CMTM8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.816	0.947	<.001	139	view →
KIRC	DFS	Median	All	0.732	0.522	<.001	85	view →
UVM	DFS	Quartile	All	0.385	0.959	<.001	46	view →
ESCA	OS	Median	All	0.620	0.785	.006	46	view →
SCLC	DFS	Tertile	II,III,IV	0.311	0.685	.003	44	view →
LUAD	OS	Tertile	III,IV	0.452	0.198	.009	25	view →
SKCM	OS	Median	All	0.402	0.262	<.001	21	view →
CHOL	DFS	Median	II,III,IV	0.222	0.553	.022	18	view →
SARC	OS	Tertile	All	0.502	0.795	<.001	17	view →
KICH	DFS	Median	II,III,IV	0.594	0.918	.009	13	view →
BLCA	OS	Quartile	III,IV	0.284	0.577	.007	13	view →
LGG	OS	Quartile	All	0.360	0.660	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CMTM8–KIRP (OS)

Open the KIRP breakdown →