CMTM6

Across TCGA patient cohorts, CMTM6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMTM6-associated genes across cancer lineages are 14-3-3_beta, GSK-3a-b_pS21_S9, and JNK2. Each is linked with CMTM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMTM6-to-partner and partner-to-CMTM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CMTM6-low versus CMTM6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTM6→partner) and Y-score (partner→CMTM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.130	-2.979	.007	.036	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.477	+2.331	.020	.019	3	1
UCEC	JNK2 →	+0.236	+2.834	.014	.034	3	1
UCEC	MSH2 →	-0.355	-2.973	.001	.035	3	1
UCEC	Akt_pT308 →	+0.770	+2.999	.011	.035	3	1
UCEC	SETD2 →	-0.227	-2.459	.031	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

14-3-3_beta by CMTM6 expression — UCEC

Explore this box plot interactively →