CMTM6

Across TCGA cell cohorts, CMTM6 mutation is significantly associated with the mutation status of many other genes, with 751 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CMTM6-associated genes across cancer lineages are NAA40, NEK2, and ERAL1. Each is linked with CMTM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMTM6-to-partner and partner-to-CMTM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAA40 grouped by CMTM6-low versus CMTM6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTM6→partner) and Y-score (partner→CMTM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NAA40 →	+6.321	+6.321	.001	.001	1	2
BLOOD_Leukemia	NEK2 →	+5.321	+5.894	.002	.002	1	2
LARGE_INTESTINE	ERAL1 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	CHIT1 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	VPS37B →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	M1AP →	+5.523	+5.523	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 751 associations by consensus.

NAA40 by CMTM6 expression — BLOOD_Leukemia

Explore this box plot interactively →