CMTM5

Across TCGA patient cohorts, CMTM5 mutation is significantly associated with the RNA expression of many other genes, with 1,415 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMTM5-associated genes across cancer lineages are FAM96AP1, UHRF1, and MIR8058. Each is linked with CMTM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CMTM5-to-partner and partner-to-CMTM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM96AP1 grouped by CMTM5-low versus CMTM5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTM5→partner) and Y-score (partner→CMTM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FAM96AP1 →	+0.055	+3.990	<.001	.009	3	3
UCEC	UHRF1 →	+1.239	+4.098	<.001	<.001	3	2
SKCM	MIR8058 →	+0.584	+3.207	<.001	.001	3	2
UCEC	MEX3D →	+0.645	+3.828	.001	<.001	3	2
UCEC	TBC1D9B →	+0.470	+3.711	<.001	<.001	3	2
UCEC	UNC13B →	+0.390	+2.740	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,415 associations by consensus.

FAM96AP1 by CMTM5 expression — SKCM

Explore this box plot interactively →