CMTM5

Across TCGA pan-cancer cohorts, CMTM5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CMTM5’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CMTM5 RNA is repressed in tumor relative to normal tissue. In most cancer types CMTM5 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KICH are the cancer types where CMTM5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CMTM5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	IV	−1.191	<.001	12	view →
COAD	Male	II,III,IV	−1.003	<.001	12	view →
KICH	Female	All	−0.553	<.001	11	view →
THCA	All	III,IV	−0.211	<.001	11	view →
LUAD	Female	III,IV	−0.711	<.001	9	view →
KIRP	Male	All	−0.312	<.001	9	view →
STAD	All	All	−0.843	<.001	8	view →
KIRC	All	II,III,IV	−0.166	<.001	8	view →
READ	All	III,IV	−1.275	<.001	7	view →
LUSC	Male	II,III,IV	−0.591	<.001	7	view →
UCEC	All	III,IV	−1.040	<.001	6	view →
BRCA	Female	II,III,IV	−0.861	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CMTM5–BLCA

Open the BLCA breakdown →