CMTM5

Across TCGA cell cohorts, CMTM5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,228 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CMTM5-associated GO terms across cancer lineages are Negative regulation of substrate adhesion-dependent cell spreading, Mitochondrial gene expression, and Pointed-end actin filament capping. Each is linked with CMTM5 in more than 4 cancer types. Because this analysis shows association rather than direction, both CMTM5-to-partner and partner-to-CMTM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of substrate adhesion-dependent cell spreading grouped by CMTM5-low versus CMTM5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTM5→partner) and Y-score (partner→CMTM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of substrate adhesion-dependent cell spreading →	+0.070	+1.046	.004	.005	3	5
SOFT_TISSUE	Mitochondrial gene expression →	+0.045	+0.085	.006	.001	3	4
BONE	Pointed-end actin filament capping →	-0.890	-0.690	.001	.008	3	4
BLOOD_Leukemia	Viral protein processing →	+0.062	+1.387	<.001	.003	2	5
BONE	D-glucuronate catabolic process to D-xylulose 5-phosphate →	+0.273	+1.076	<.001	<.001	3	4
BLOOD_Leukemia	Regulation of transepithelial transport →	+0.017	+1.011	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,228 associations by consensus.

Negative regulation of substrate adhesion-dependent cell spreading by CMTM5 expression — SKIN

Explore this box plot interactively →