CMC4

Across TCGA patient cohorts, CMC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,862 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CMC4-associated GO terms across cancer lineages are Postsynaptic membrane assembly, Methylglyoxal metabolic process, and DNA replication, synthesis of primer. Each is linked with CMC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CMC4-to-partner and partner-to-CMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Postsynaptic membrane assembly grouped by CMC4-low versus CMC4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CMC4→partner) and Y-score (partner→CMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Postsynaptic membrane assembly →	+0.065	+0.111	<.001	<.001	3	4
READ	Methylglyoxal metabolic process →	+0.035	+0.045	.001	.003	3	4
SCLC	DNA replication, synthesis of primer →	+0.167	+0.781	<.001	<.001	3	3
SCLC	Endoplasmic reticulum tubular network formation →	-0.209	-0.763	<.001	<.001	3	3
ESCA	Chemokine (C-X-C motif) ligand 1 production →	+0.055	+0.097	.001	<.001	3	3
ESCA	Establishment of planar polarity involved in neural tube closure →	+0.083	+0.099	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,862 associations by consensus.

Postsynaptic membrane assembly by CMC4 expression — STAD

Explore this box plot interactively →