CMC4

Across TCGA cell cohorts, CMC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,647 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CMC4-associated GO terms across cancer lineages are Lactation, Ribosomal large subunit biogenesis, and Proton-transporting two-sector ATPase complex assembly. Each is linked with CMC4 in more than 8 cancer types. Because this analysis shows association rather than direction, both CMC4-to-partner and partner-to-CMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lactation grouped by CMC4-low versus CMC4-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CMC4→partner) and Y-score (partner→CMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Lactation →	-0.128	-0.840	<.001	<.001	3	9
BONE	Ribosomal large subunit biogenesis →	-0.113	-0.827	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Proton-transporting two-sector ATPase complex assembly →	+0.105	+0.818	.001	.001	2	9
BONE	Mitochondrial tRNA pseudouridine synthesis →	-0.135	-0.743	<.001	.005	3	7
LUNG_NSCLC_LUAD	Male meiosis I →	+0.070	+0.721	.001	.002	3	7
BLOOD_Leukemia	Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway →	+0.103	+0.913	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,647 associations by consensus.

Lactation by CMC4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →