CMA1

Across TCGA patient cohorts, CMA1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMA1-associated genes across cancer lineages are PTEN, YB-1, and FoxM1. Each is linked with CMA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMA1-to-partner and partner-to-CMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTEN grouped by CMA1-low versus CMA1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMA1→partner) and Y-score (partner→CMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PTEN →	+0.480	+3.000	.030	.036	3	1
SKCM	YB-1 →	+0.291	+2.820	.013	.035	3	1
UCEC	FoxM1 →	+0.357	+2.817	.008	.036	3	1
UCEC	ACC1 →	+0.526	+2.820	.005	.035	3	1
UCEC	Ku80 →	+0.420	+3.335	<.001	.005	3	1
UCEC	Rab11 →	-0.234	-3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PTEN by CMA1 expression — SKCM

Explore this box plot interactively →