CLYBL

Across TCGA pan-cancer cohorts, CLYBL Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CLYBL data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CLYBL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CLYBL expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, ESCA, and BLCA are the cancer types where CLYBL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	II,III,IV	0.628	0.913	.001	18	view →
ESCA	OS	Median	II,III,IV	0.248	0.686	.019	9	view →
BLCA	OS	Median	IV	0.132	0.599	.004	6	view →
UCEC	DFS	Median	II,III,IV	0.915	0.436	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CLYBL–BRCA (OS)

Open the BRCA breakdown →