CLYBL

Across TCGA pan-cancer cohorts, CLYBL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CLYBL’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CLYBL RNA is repressed in tumor relative to normal tissue. In most cancer types CLYBL is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and BLCA are the cancer types where CLYBL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLYBL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.245	<.001	11	view →
KIRP	All	III,IV	−1.114	<.001	11	view →
BLCA	Male	III,IV	−1.418	<.001	10	view →
HNSC	Male	All	−0.821	<.001	10	view →
KIRC	Male	IV	−0.937	<.001	8	view →
COAD	Female	All	−0.691	<.001	8	view →
BRCA	All	III,IV	−0.758	<.001	6	view →
UCEC	All	All	−0.643	<.001	6	view →
KICH	All	All	−0.671	.001	5	view →
READ	All	All	−0.647	.001	5	view →
CHOL	All	All	−1.428	<.001	3	view →
LUSC	All	II,III,IV	−0.325	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CLYBL–THCA

Open the THCA breakdown →