CLYBL

Across TCGA pan-cancer cohorts, CLYBL mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CLYBL data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CLYBL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CLYBL expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and LSCC are the cancer types where CLYBL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.823	.019	48	view →
PDAC	OS	Median	II,III,IV	0.980	0.685	.001	24	view →
LSCC	DFS	Quartile	II,III,IV	0.436	0.838	.004	13	view →
LUAD	DFS	Tertile	All	0.934	0.554	.018	9	view →
HNSC	DFS	Tertile	II,III,IV	0.874	0.989	.011	7	view →
CCRCC	DFS	Quartile	All	1.000	0.593	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CLYBL–COAD (DFS)

Open the COAD breakdown →