CLYBL

Across TCGA patient cohorts, CLYBL mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLYBL-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR_pY1068. Each is linked with CLYBL in more than 1 cancer types. Because this analysis shows association rather than direction, both CLYBL-to-partner and partner-to-CLYBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CLYBL-low versus CLYBL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLYBL→partner) and Y-score (partner→CLYBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.121	+3.720	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.111	-2.973	.011	.035	3	1
UCEC	EGFR_pY1068 →	-0.299	-2.115	.006	.019	3	1
UCEC	A-Raf_pS299 →	-0.134	-2.115	.010	.019	3	1
UCEC	FoxM1 →	+0.296	+3.009	.008	.019	3	1
UCEC	JNK2 →	+0.187	+2.115	.031	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by CLYBL expression — UCEC

Explore this box plot interactively →