CLVS1

Across TCGA patient cohorts, CLVS1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,897 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLVS1-associated genes across cancer lineages are PICK1, SLC16A8, and NEFH. Each is linked with CLVS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLVS1-to-partner and partner-to-CLVS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLVS1 versus PICK1 in GBM, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLVS1→partner) and Y-score (partner→CLVS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PICK1 →	+0.343	+0.375	<.001	.002	3	1
GBM	SLC16A8 →	+0.573	+0.539	<.001	<.001	3	1
GBM	NEFH →	+1.089	+0.485	<.001	<.001	3	1
GBM	RASD2 →	+0.718	+0.665	<.001	<.001	3	1
GBM	SYNGR1 →	+0.827	+0.450	<.001	<.001	3	1
GBM	CACNA1I →	+0.632	+0.518	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,897 associations by consensus.

CLVS1 vs PICK1 — GBM

Explore this scatter interactively →