CLVS1

Across TCGA pan-cancer cohorts, CLVS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CLVS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CLVS1 RNA is repressed in tumor relative to normal tissue. In most cancer types CLVS1 is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where CLVS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLVS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.312	<.001	11	view →
KIRC	All	II,III,IV	+0.046	<.001	10	view →
THCA	Male	All	−0.313	<.001	9	view →
LIHC	Male	All	+0.243	<.001	6	view →
BRCA	All	III,IV	−0.223	<.001	6	view →
KIRP	All	All	+0.125	.005	4	view →
LUAD	All	All	+0.092	.010	3	view →
CHOL	All	All	+0.559	<.001	2	view →
PRAD	All	All	−0.040	.005	2	view →
KICH	All	IV	+0.065	.035	1	view →
COAD	Female	II,III,IV	+0.037	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CLVS1–HNSC

Open the HNSC breakdown →