CLVS1

Across TCGA patient cohorts, CLVS1 mutation is significantly associated with the RNA expression of many other genes, with 3,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLVS1-associated genes across cancer lineages are NR2C2AP, PRR29, and LINC02585. Each is linked with CLVS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLVS1-to-partner and partner-to-CLVS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NR2C2AP grouped by CLVS1-low versus CLVS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLVS1→partner) and Y-score (partner→CLVS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NR2C2AP →	+0.500	+2.627	<.001	<.001	3	3
UCEC	PRR29 →	-1.039	-2.263	<.001	<.001	3	3
UCEC	LINC02585 →	+0.449	+2.002	.004	<.001	3	3
UCEC	MTHFD1 →	+0.549	+3.269	<.001	<.001	3	3
UCEC	CENPA →	+0.590	+2.263	.004	<.001	3	3
UCEC	ITGB1BP1 →	+0.334	+2.518	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,660 associations by consensus.

NR2C2AP by CLVS1 expression — UCEC

Explore this box plot interactively →