CLVS1

Across TCGA patient cohorts, CLVS1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLVS1-associated genes across cancer lineages are Notch1, p70-S6K_pT389, and Bak. Each is linked with CLVS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLVS1-to-partner and partner-to-CLVS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CLVS1-low versus CLVS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLVS1→partner) and Y-score (partner→CLVS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.185	+2.820	<.001	.001	3	2
UCEC	p70-S6K_pT389 →	-0.163	-2.999	.017	.035	3	2
UCEC	Bak →	+0.190	+1.874	.035	.049	3	2
UCEC	BRD4 →	+0.226	+1.685	.027	.014	3	2
UCEC	Caspase-7-cleavedD198 →	+0.586	+1.720	.006	.025	3	2
UCEC	C-Raf →	+0.140	+1.700	.006	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Notch1 by CLVS1 expression — UCEC

Explore this box plot interactively →