CLVS1

Across TCGA cell cohorts, CLVS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,711 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CLVS1-associated GO terms across cancer lineages are Positive regulation of intracellular sterol transport, Positive regulation of intracellular cholesterol transport, and Response to arachidonate. Each is linked with CLVS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both CLVS1-to-partner and partner-to-CLVS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular sterol transport grouped by CLVS1-low versus CLVS1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLVS1→partner) and Y-score (partner→CLVS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of intracellular sterol transport →	+0.082	+0.118	.002	.002	3	6
OESOPHAGUS	Positive regulation of intracellular cholesterol transport →	+0.082	+0.118	.002	.002	3	6
BONE	Response to arachidonate →	-0.187	-0.152	.001	.002	3	5
BONE	Positive regulation of potassium ion import across plasma membrane →	+0.147	+0.139	.008	.009	2	5
PANCREAS	Cell cycle DNA replication initiation →	-0.160	-0.176	<.001	.002	2	5
PANCREAS	Nuclear cell cycle DNA replication initiation →	-0.160	-0.176	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,711 associations by consensus.

Positive regulation of intracellular sterol transport by CLVS1 expression — OESOPHAGUS

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