CLVS1

Across TCGA cell cohorts, CLVS1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CLVS1-associated genes across cancer lineages are MSGN1, TAFA1, and OR4X2. Each is linked with CLVS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLVS1-to-partner and partner-to-CLVS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by CLVS1-low versus CLVS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLVS1→partner) and Y-score (partner→CLVS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.126	+4.930	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
SKIN	OR4X2 →	+0.017	+3.930	.001	.003	3	1
SKIN	OR56A5 →	+0.047	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MSGN1 by CLVS1 expression — LARGE_INTESTINE

Explore this box plot interactively →