CLUL1

Across TCGA cell cohorts, CLUL1 mutation is significantly associated with the RNA expression of many other genes, with 183 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLUL1-associated genes across cancer lineages are SPATA31D1, USP17L20, and USP17L18. Each is linked with CLUL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLUL1-to-partner and partner-to-CLUL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31D1 grouped by CLUL1-low versus CLUL1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLUL1→partner) and Y-score (partner→CLUL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1
BLOOD_Leukemia	USP17L20 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP17L18 →	+0.006	+5.539	<.001	.003	3	1
LARGE_INTESTINE	UHRF1BP1L →	+0.566	+3.212	.005	.006	3	1
LARGE_INTESTINE	MRPS30 →	+0.493	+3.184	.004	.007	3	1
LARGE_INTESTINE	POLR3G →	+1.074	+3.212	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 183 associations by consensus.

SPATA31D1 by CLUL1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →