Across TCGA pan-cancer cohorts, CLUHP8 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CLUHP8’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CLUHP8 RNA is repressed in tumor relative to normal tissue. In most cancer types CLUHP8 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC are the cancer types where CLUHP8 tumor–normal differential expression is most reproducible.