CLTRN

Across TCGA patient cohorts, CLTRN mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLTRN-associated genes across cancer lineages are FASN, JNK_pT183_Y185, and Notch1. Each is linked with CLTRN in more than 1 cancer types. Because this analysis shows association rather than direction, both CLTRN-to-partner and partner-to-CLTRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by CLTRN-low versus CLTRN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTRN→partner) and Y-score (partner→CLTRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.435	+3.584	.022	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.192	-2.999	.018	.035	3	1
UCEC	Notch1 →	+0.230	+3.009	<.001	.019	3	1
UCEC	PDCD4 →	-0.738	-3.449	.001	.005	3	1
UCEC	TIGAR →	+0.147	+2.486	.045	.011	3	1
UCEC	Cyclin-B1 →	+0.814	+3.584	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FASN by CLTRN expression — UCEC

Explore this box plot interactively →