CLSTN1

Across TCGA cell cohorts, CLSTN1 mutation is significantly associated with the drug of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLSTN1-associated genes across cancer lineages are PD0325901, 5-Fluorouracil, and CP466722. Each is linked with CLSTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLSTN1-to-partner and partner-to-CLSTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PD0325901 grouped by CLSTN1-low versus CLSTN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLSTN1→partner) and Y-score (partner→CLSTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PD0325901 →	-0.504	-2.745	.047	.047	3	1
LARGE_INTESTINE	5-Fluorouracil →	+0.609	+2.991	.026	.018	3	1
LARGE_INTESTINE	CP466722 →	+0.427	+2.874	.022	.021	3	1
LARGE_INTESTINE	LCL161 →	+0.360	+2.868	.019	.022	3	1
LARGE_INTESTINE	Bromosporine →	+0.350	+2.871	.032	.021	3	1
LARGE_INTESTINE	AZD5991 →	+0.885	+2.871	.014	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PD0325901 by CLSTN1 expression — LARGE_INTESTINE

Explore this box plot interactively →