CLSTN1

Across TCGA pan-cancer cohorts, CLSTN1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CLSTN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CLSTN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CLSTN1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KICH, and LUAD are the cancer types where CLSTN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLSTN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+1.392	<.001	12	view →
KICH	Male	All	−1.610	<.001	8	view →
LUAD	All	II,III,IV	+0.705	<.001	8	view →
LUSC	Male	II,III,IV	+1.612	<.001	7	view →
LIHC	Female	II,III,IV	+1.763	<.001	6	view →
UCEC	All	All	−0.810	<.001	6	view →
BLCA	All	III,IV	+0.542	.003	6	view →
CHOL	Female	All	+3.143	<.001	5	view →
STAD	All	All	+0.778	.001	5	view →
COAD	Female	II,III,IV	−0.431	.001	4	view →
READ	All	II,III,IV	−0.807	.004	3	view →
PAAD	All	All	+1.135	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CLSTN1–HNSC

Open the HNSC breakdown →