CLSPN

Across TCGA patient cohorts, CLSPN mutation is significantly associated with the RNA expression of many other genes, with 2,409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLSPN-associated genes across cancer lineages are RNU6-19P, LSM10, and NDUFAF1. Each is linked with CLSPN in more than 2 cancer types. Because this analysis shows association rather than direction, both CLSPN-to-partner and partner-to-CLSPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-19P grouped by CLSPN-low versus CLSPN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLSPN→partner) and Y-score (partner→CLSPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-19P →	+0.931	+3.109	<.001	.004	3	3
UCEC	LSM10 →	+0.304	+1.807	<.001	<.001	3	3
UCEC	NDUFAF1 →	+0.345	+1.470	<.001	<.001	3	3
BRCA	RN7SKP169 →	+0.253	+5.683	<.001	.004	3	3
READ	FTH1P14 →	+0.157	+4.653	<.001	.007	3	2
READ	LINC00437 →	+0.246	+4.925	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,409 associations by consensus.

RNU6-19P by CLSPN expression — LUAD

Explore this box plot interactively →