CLSPN

Across TCGA pan-cancer cohorts, CLSPN RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CLSPN’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CLSPN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CLSPN is over-expressed in tumor.

BLCA, HNSC, and KIRP are the cancer types where CLSPN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLSPN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	+2.207	<.001	12	view →
HNSC	Male	All	+1.812	<.001	12	view →
KIRP	All	III,IV	+1.188	<.001	11	view →
COAD	Female	II,III,IV	+1.173	<.001	11	view →
KIRC	Male	All	+0.832	<.001	11	view →
STAD	Female	All	+2.377	<.001	10	view →
LUAD	Male	III,IV	+2.688	<.001	9	view →
LIHC	Male	All	+0.756	<.001	9	view →
LUSC	Female	All	+2.660	<.001	8	view →
THCA	All	III,IV	+0.403	<.001	8	view →
UCEC	All	III,IV	+2.866	<.001	6	view →
BRCA	All	II,III,IV	+1.812	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CLSPN–BLCA

Open the BLCA breakdown →