CLSPN

Across TCGA patient cohorts, CLSPN mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLSPN-associated genes across cancer lineages are eEF2, eIF4E, and Fibronectin. Each is linked with CLSPN in more than 1 cancer types. Because this analysis shows association rather than direction, both CLSPN-to-partner and partner-to-CLSPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CLSPN-low versus CLSPN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLSPN→partner) and Y-score (partner→CLSPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.244	+1.906	.016	.014	3	2
UCEC	eIF4E →	+0.208	+2.237	<.001	<.001	3	2
UCEC	Fibronectin →	-0.238	-1.653	.011	.010	3	2
UCEC	GAPDH →	+0.309	+1.678	.042	.019	3	2
UCEC	mTOR_pS2448 →	-0.105	-1.349	.013	.031	3	2
UCEC	PCNA →	+0.150	+1.398	.014	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

eEF2 by CLSPN expression — UCEC

Explore this box plot interactively →