CLSPN

Across TCGA cell cohorts, CLSPN mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLSPN-associated genes across cancer lineages are OR56A4, SLC30A10, and GPR6. Each is linked with CLSPN in more than 1 cancer types. Because this analysis shows association rather than direction, both CLSPN-to-partner and partner-to-CLSPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A4 grouped by CLSPN-low versus CLSPN-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLSPN→partner) and Y-score (partner→CLSPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR56A4 →	+0.008	+3.977	<.001	.007	3	2
LUNG_NSCLC_LUAD	SLC30A10 →	+0.401	+3.370	<.001	.008	3	2
SOFT_TISSUE	GPR6 →	+0.010	+3.977	<.001	.007	3	1
SOFT_TISSUE	CRYBA4 →	+0.371	+3.936	.004	.002	3	1
SOFT_TISSUE	TEX43 →	+0.082	+3.584	<.001	.004	3	1
SOFT_TISSUE	GPR142 →	+0.043	+3.297	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

OR56A4 by CLSPN expression — SOFT_TISSUE

Explore this box plot interactively →