CLRN1

Across TCGA patient cohorts, CLRN1 mutation is significantly associated with the RNA expression of many other genes, with 1,144 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLRN1-associated genes across cancer lineages are RNU6-218P, RNA5SP509, and FEN1. Each is linked with CLRN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLRN1-to-partner and partner-to-CLRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-218P grouped by CLRN1-low versus CLRN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLRN1→partner) and Y-score (partner→CLRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-218P →	+0.255	+1.729	.006	.007	3	3
LGG	RNA5SP509 →	+0.248	+7.977	<.001	.007	3	3
UCEC	FEN1 →	+0.586	+3.807	.003	<.001	3	3
UCEC	MTCH2 →	+0.422	+2.550	.002	<.001	3	3
LUSC	RNA5SP521 →	+0.312	+3.370	.004	.008	3	3
SKCM	NDUFS3 →	+0.376	+3.613	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,144 associations by consensus.

RNU6-218P by CLRN1 expression — SKCM

Explore this box plot interactively →