CLPTM1L

Across TCGA patient cohorts, CLPTM1L mutation is significantly associated with the RNA expression of many other genes, with 2,581 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLPTM1L-associated genes across cancer lineages are LONRF2P2, UQCR11, and BAIAP2L2. Each is linked with CLPTM1L in more than 2 cancer types. Because this analysis shows association rather than direction, both CLPTM1L-to-partner and partner-to-CLPTM1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LONRF2P2 grouped by CLPTM1L-low versus CLPTM1L-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPTM1L→partner) and Y-score (partner→CLPTM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	LONRF2P2 →	+0.056	+6.593	<.001	<.001	3	3
UCEC	UQCR11 →	+0.421	+3.981	<.001	<.001	3	2
UCEC	BAIAP2L2 →	+1.387	+2.180	<.001	.001	3	2
UCEC	CLN6 →	+0.400	+3.860	<.001	<.001	3	2
UCEC	MPDU1 →	+0.329	+2.606	.006	.005	3	2
UCEC	TUBG1 →	+0.693	+3.868	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,581 associations by consensus.

LONRF2P2 by CLPTM1L expression — LUSC

Explore this box plot interactively →