CLPTM1

Across TCGA pan-cancer cohorts, CLPTM1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CLPTM1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CLPTM1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CLPTM1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LUAD, CCRCC, and COAD are the cancer types where CLPTM1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLPTM1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.565	<.001	9	view →
CCRCC	Male	All	−0.473	<.001	9	view →
COAD	Male	All	+0.187	<.001	9	view →
LSCC	Female	All	+0.538	<.001	8	view →
HNSC	Male	II,III,IV	+0.250	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CLPTM1–LUAD

Open the LUAD breakdown →