CLPTM1

Across TCGA pan-cancer cohorts, CLPTM1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CLPTM1 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher CLPTM1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CLPTM1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and DLBC show a favorable association.

MESO, ACC, and LGG are the cancer types where CLPTM1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.255	0.495	<.001	95	view →
ACC	DFS	Median	All	0.417	0.743	<.001	70	view →
LGG	DFS	Median	All	0.683	0.794	.001	34	view →
SCLC	OS	Quartile	All	0.496	0.203	.020	25	view →
OV	OS	Quartile	All	0.634	0.750	.006	24	view →
LUAD	OS	Quartile	All	0.235	0.532	.002	22	view →
LIHC	DFS	Quartile	All	0.483	0.645	.006	21	view →
DLBC	OS	Median	IV	1.000	0.362	.003	18	view →
KIRP	DFS	Median	IV	0.037	0.526	.010	18	view →
SKCM	OS	Tertile	All	0.734	0.826	.001	13	view →
PAAD	OS	Quartile	All	0.543	0.232	.002	12	view →
LUSC	DFS	Median	III,IV	0.434	0.884	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CLPTM1–MESO (OS)

Open the MESO breakdown →