CLPTM1

Across TCGA patient cohorts, CLPTM1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLPTM1-associated genes across cancer lineages are EGFR_pY1068, PRDX1, and MYH11. Each is linked with CLPTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPTM1-to-partner and partner-to-CLPTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CLPTM1-low versus CLPTM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPTM1→partner) and Y-score (partner→CLPTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.224	-2.999	.023	.035	3	2
UCEC	PRDX1 →	+0.237	+2.584	.003	.010	3	2
SKCM	MYH11 →	-0.829	-2.222	.022	.010	3	2
SKCM	14-3-3_epsilon →	+0.134	+3.169	.008	.018	3	2
SKCM	VHL →	-0.595	-3.000	.040	.034	3	2
UCEC	eEF2 →	+0.298	+1.584	.033	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by CLPTM1 expression — UCEC

Explore this box plot interactively →