CLPTM1

Across TCGA cell cohorts, CLPTM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,865 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CLPTM1-associated GO terms across cancer lineages are Phospholipid biosynthetic process, Negative regulation of calcium ion export across plasma membrane, and Multi-pass transmembrane protein insertion into ER membrane. Each is linked with CLPTM1 in more than 12 cancer types. Because this analysis shows association rather than direction, both CLPTM1-to-partner and partner-to-CLPTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phospholipid biosynthetic process grouped by CLPTM1-low versus CLPTM1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPTM1→partner) and Y-score (partner→CLPTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Phospholipid biosynthetic process →	+0.049	+0.727	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.077	+0.697	.002	<.001	3	13
BLOOD_Lymphoma	Multi-pass transmembrane protein insertion into ER membrane →	+0.128	+0.818	.001	<.001	3	12
BREAST	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.108	+0.838	.002	<.001	3	12
LIVER	Membrane protein proteolysis →	+0.131	+0.767	<.001	.001	3	11
URINARY_TRACT	Vacuolar transport →	+0.057	+0.641	.003	.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,865 associations by consensus.

Phospholipid biosynthetic process by CLPTM1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →